Which statement best describes the role of the IACUC during protocol review?

• A. The protocol is the only document reviewed; welfare standards are separate.
• B. The IACUC reviews the study plan, welfare measures, and compliance with standards.
• C. The IACUC only reviews budgets and timelines.
• D. The IACUC is not responsible for welfare monitoring after approval.

Answer: (B)

The main idea being tested is that protocol review centers on animal welfare within the study design and ensuring adherence to standards. The IACUC examines the entire plan for using animals: the study design itself, the specific welfare measures that will minimize pain and distress (such as anesthesia and analgesia plans, monitoring, and humane endpoints), and how well the proposal aligns with applicable laws, regulations, and institutional policies. It also considers animal numbers, justification, and whether alternatives have been explored, along with housing, enrichment, and veterinary care.

Budgets or timelines are not the focus of the welfare review, and welfare oversight continues after approval through ongoing monitoring and inspections. But the initial protocol review is about making sure the plan, the protections for animal welfare, and the standards are integrated from the start. That combination is what makes this description the best fit.