What is the role of the Institutional Animal Care and Use Committee (IACUC)?

• A. To fund research
• B. To review and approve procedures involving animals
• C. To inspect facilities
• D. To license veterinarians

Answer: (B)

The core idea here is that IACUC acts as the guardian of humane and compliant animal use within an institution. Its primary job is to review and approve all procedures involving animals before they are carried out. This means investigators submit a detailed protocol describing the animal species, numbers, housing and husbandry, exact procedures, anesthesia or analgesia plans, potential pain or distress, humane endpoints, and the scientific justification for using animals. The committee evaluates whether the use is scientifically justified, whether alternatives have been considered, and whether the proposed measures will minimize pain and distress to the animals. It also checks that personnel are properly trained and that facilities meet welfare standards. While IACUCs may conduct facility and program inspections and can suspend or modify work if concerns arise, the essential function is the rigorous review and approval of animal-use procedures to ensure ethical and regulatory compliance.