What is the recommended immediate response to unexpected adverse welfare events during a study?

• A. Suspend procedures immediately without reporting.
• B. Notify the Attending Veterinarian and IACUC, suspend procedures if needed, and implement corrective actions.
• C. Continue as planned and document later.
• D. Ignore the event if it seems minor.

Answer: (B)

Immediate protection of animal welfare and regulatory compliance requires escalation and action. The recommended response is to notify the Attending Veterinarian and the IACUC, suspend procedures if needed to prevent further harm, and implement corrective actions to address the cause and prevent recurrence. This sequence ensures expert welfare assessment, rapid risk mitigation, and adherence to institutional and regulatory requirements.

Corrective actions can include medical care for affected animals, revising anesthesia or analgesia plans, adjusting humane endpoints, modifying husbandry or handling, providing additional training for personnel, or amending the study protocol. Documenting the event and following up with the IACUC ensures proper oversight and helps determine whether the study can continue, after changes, or needs termination. Avoid continuing as planned, delaying reporting, or ignoring the event, as these undermine animal welfare and compliance.